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目的总结耐多药肺结核患者对氧氟沙星、卡那霉素二线抗结核药物的敏感性。方法随机筛选昆明市第三人民医2014年10月至2015年10月期间收治的耐多药肺结核患者共216例,分析患者分离株对于氧氟沙星、卡那霉素二线抗结核药物的敏感性。结果结果显示,卡那霉素耐药27例(12.5%);氧氟沙星耐药89例(41.2%);针对氧氟沙星、卡那霉素两种二线抗结核药物同时耐药的有19例(8.8%);不同登记分类耐多药肺结核二线药敏结果中,复治患者氧氟沙星耐药高于初治(P<0.05);不同类别来源患者二线药敏结果中,广泛耐药结核病患者25例,有6例复发,13例复治失败。结论耐多药肺结核患者对氧氟沙星、卡那霉素二线抗结核药物的耐药性非常高,临床需增强二线抗结核药物敏感性检测的能力,并在肺结核治疗期间严加监管,以免出现不规则操作、药物滥用等情况,以降低广泛耐多药肺结核发生率。
Objective To summarize the susceptibility of second-line anti-tuberculosis drugs to ofloxacin and kanamycin in patients with multidrug-resistant pulmonary tuberculosis. Methods A total of 216 MDR-TB patients admitted to the Third People’s Hospital of Kunming from October 2014 to October 2015 were randomly selected to analyze the sensitivity of the patient isolates to ofloxacin and kanamycin second-line anti-tuberculosis drugs Sex. The results showed that kanamycin resistance in 27 cases (12.5%), ofloxacin drug resistance in 89 cases (41.2%); ofloxacin, kanamycin two kinds of second-line anti-TB drug resistance (19 cases, 8.8%). Of the second-line drug-susceptibility results of MDR-TB in different registration categories, ofloxacin-resistant patients were higher than those of initial treatment (P <0.05). Among the second-line drug- Twenty - five patients with extensively drug - resistant TB were relapsed in 6 and failed in 13. Conclusion MDR-TB resistance to ofloxacin and kanamycin second-line anti-TB drugs is very high. The clinical need to enhance the sensitivity of second-line anti-TB drug testing and strict supervision during tuberculosis treatment should be avoided Irregular operation, drug abuse, etc., to reduce the incidence of widespread MDR-TB.