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目的探讨环氧化酶-2在Hp阳性胃炎中的表达及与炎症的关系。方法收集在潍坊市妇幼保健院行胃镜检查慢性胃炎患者为对象。入选患者80例,采集20例对照组,30例Hp阴性慢性胃炎,30例Hp阳性慢性胃炎患者的活检标本,应用免疫组化法测定胃黏膜中环氧化酶-2(COX-2)在三组中的表达,以及在Hp阳性慢性胃炎COX-2的表达与炎症程度的关系。结果Hp阳性的慢性胃炎组织中的COX-2阳性表达率明显高于对照组(P<0.01),差异有统计学意义;Hp阳性的慢性胃炎组织中的COX-2阳性表达率明显高于Hp阴性的慢性胃炎组织(P<0.01),差异有统计学意义。结论COX-2在Hp阳性胃炎的发生发展中起重要作用,对评价胃炎的进展程度和预后有一定的参考价值,为治疗方案的选择提供依据。
Objective To investigate the expression of cyclooxygenase-2 in Hp-positive gastritis and its relationship with inflammation. Methods We collected the patients with chronic gastritis underwent endoscopy in Weifang Maternal and Child Health Hospital. Totally 80 patients were enrolled in this study. Twenty biopsy specimens of Hp-negative chronic gastritis and 30 Hp-positive chronic gastritis were collected from 20 control subjects. The expression of cyclooxygenase-2 (COX-2) in gastric mucosa was detected by immunohistochemistry in three groups And the relationship between the expression of COX-2 and the degree of inflammation in Hp-positive chronic gastritis. Results The positive rate of COX-2 in Hp-positive chronic gastritis was significantly higher than that in the control (P <0.01), and the difference was statistically significant. The positive rate of COX-2 in Hp-positive chronic gastritis was significantly higher than that in Hp Negative chronic gastritis (P <0.01), the difference was statistically significant. Conclusions COX-2 plays an important role in the occurrence and development of Hp-positive gastritis. It is of great value to evaluate the progression and prognosis of gastritis, and provide a basis for the selection of treatment options.