目前人们利用亚硝胺类化合物诱发动物肿瘤研究方面已经进行了大量工作,但对其诱癌过程中动物的全身反应报道甚少。本实验采用二亚硝基哌嗪(Din-itrosopiperazine,DNP)诱发大鼠肿瘤,在给药前后不同阶段检测动物血液中白细胞,尤其淋巴细胞及其亚群数量的变化,以观察DNP对动物免疫状态的影响。 At present, a great deal of work has been done on the use of nitrosamines to induce animal tumors, but there have been very few reports on the systemic responses of animals to their carcinogenesis. In this study, DNP was used to induce rat tumors. The changes of leukocytes, especially the number of lymphocytes and their subpopulations, were measured at different stages before and after administration to observe the effects of DNP on animals. State effects.