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目的观察5单硝酸异山梨酯联合美托洛尔治疗心绞痛的疗效。方法采用随机、单盲法将59例心绞痛患者分为两组。治疗组30例,给予5单硝酸异山梨酯联合美托洛尔治疗;对照组29例,给予5单硝酸异山梨酯治疗;观察两组患者用药后各项指标的改善情况并进行比较。结果治疗组总有效率93.3%,对照组为58.6%,组间比较有显著性差异(P<0.01);治疗组心电图改善总有效率66.7%,对照组为40.7%,组间比较有显著性差异(P<0.05)。结论5单硝酸异山梨酯联合美托洛尔治疗心绞痛疗效优于单用5单硝酸异山梨酯。
Objective To observe the efficacy of isosorbide mononitrate combined with metoprolol in the treatment of angina pectoris. Methods Fifty-nine patients with angina pectoris were divided into two groups by randomized, single-blind method. The treatment group, 30 patients were given isosorbide mononitrate combined with metoprolol treatment; control group of 29 patients given 5 isosorbide mononitrate treatment; observed two groups of patients after treatment of the improvement of the indicators and compared. Results The total effective rate was 93.3% in the treatment group and 58.6% in the control group, with significant difference between the two groups (P <0.01). The total effective rate of electrocardiogram was 66.7% in the treatment group and 40.7% in the control group, with significant difference Difference (P <0.05). Conclusion Isosorbide mononitrate combined with metoprolol in the treatment of angina pectoris is better than the single 5 isosorbide mononitrate.