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脑电生理研究表明,氯丙嗪能对抗儿茶酚胺对脑电的激活反应。有些学者并作为根据之一来推论氯丙嗪的作用机制。如Brodie B. B. 1959年提出:氯丙嗪的安定作用,可以认为是阻断了脑中去甲肾上腺素的作用,从而抑制了促活动系统。但是有的药物对脑电与行为的影响并不完全一致,而存在脱节现象。肾上腺素也有类似情况,动物在深度抑制时,脑电图却呈现激活波型。本文采用防御性条件反射方法,并结合动物外表行为观察去甲肾上腺素与氯丙嗪的合并效应。实验分二部分进行。
EEG electrophysiological studies have shown that chlorpromazine can antagonize the activation of catecholamines EEG response. Some scholars use it as a basis to deduce the mechanism of action of chlorpromazine. Such as Brodie B. B. 1959 proposed: stability of chlorpromazine can be considered to block the brain norepinephrine role, thereby inhibiting the pro-active system. However, some drugs on the brain and the impact of behavior is not exactly the same, but there is a disconnect. Epinephrine also has a similar situation, the depth of inhibition in animals, the EEG shows an activation waveform. In this paper, defensive conditioning reflex method, combined with animal behavior to observe the combined effect of norepinephrine and chlorpromazine. The experiment is divided into two parts.