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目的探讨核因子κB(NF-κB)、P-gp、c-erbB-2蛋白在乳腺癌组织中的表达及其临床意义。方法采用免疫组化Power visionTM两步法检测97例乳腺癌组织中NF-κB、P-gp、c-erbB-2的表达情况。结果乳腺癌组织中NF-κB、P-gp、c-erbB-2的阳性表达率分别为65.97%、43.29%、50.51%;NF-κB、c-erbB-2与乳腺癌淋巴转移及病理分期相关(P<0.05);在乳腺癌标本中NF-κB、P-gp、c-erbB-2蛋白表达两两间均有相关性(P<0.05)。结论乳腺癌中NF-κB、P-gp、c-erbB-2三者间蛋白表达均有相关性,其在乳腺癌多药耐药发生中具有一定作用。
Objective To investigate the expression of nuclear factor κB (NF-κB), P-gp and c-erbB-2 in breast cancer and its clinical significance. Methods The expression of NF-κB, P-gp and c-erbB-2 in 97 cases of breast cancer were detected by immunohistochemistry Power visionTM two-step method. Results The positive rates of NF-κB, P-gp and c-erbB-2 in breast cancer tissues were 65.97%, 43.29% and 50.51%, respectively. The positive rates of NF-κB, c-erbB- (P <0.05). The expressions of NF-κB, P-gp and c-erbB-2 in breast cancer specimens were correlated with each other (P <0.05). Conclusion The protein expressions of NF-κB, P-gp and c-erbB-2 are all correlated in breast cancer and play a role in the development of multidrug resistance in breast cancer.