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目的探讨脑梗死与血浆同型半胱氨酸(Hcy)水平的关系,及叶酸、维生素B12的相关性。方法选择我院2010年3月~2014年12月收治的脑梗死患者40例作为观察组,另选择同期本院健康体检者40名作为对照组,治疗前检测两组Hcy、维生素B12、叶酸水平,观察组治疗后,再次检测上述指标,比较两组治疗前后各指标水平变化。结果治疗前,观察组Hcy水平显著高于对照组,差异有统计学意义(P<0.05)。治疗前观察组叶酸、维生素B12水平显著低于对照组,差异有统计学意义(P<0.05)。治疗后观察组Hcy与对照组对比,差异无统计学意义(P>0.05);Hcy与治疗前对比下降显著,差异有统计学意义(P<0.05)。治疗后观察组叶酸、维生素B12与对照组对比,差异无统计学意义(P>0.05);叶酸、维生素B12治疗后对比显著上升,差异有统计学意义(P<0.05)。结论在Hcy水平方面,脑梗死患者明显高于对照组,叶酸、维生素B12治疗可有助于降低Hcy水平,从而改善脑梗死预后。
Objective To investigate the relationship between cerebral infarction and plasma homocysteine (Hcy) levels and the correlation between folic acid and vitamin B12. Methods Forty patients with cerebral infarction who were treated in our hospital from March 2010 to December 2014 were selected as the observation group and 40 healthy subjects in the same period were selected as the control group. Before treatment, the levels of Hcy, vitamin B12, folic acid After treatment, the above indexes were tested again in the observation group, and the changes of each index before and after treatment were compared. Results Before treatment, the Hcy level in the observation group was significantly higher than that in the control group (P <0.05). Before treatment, the levels of folic acid and vitamin B12 in observation group were significantly lower than those in control group (P <0.05). After treatment, the Hcy in the observation group was significantly lower than that in the control group (P> 0.05); Hcy decreased significantly compared with that before treatment, with significant difference (P <0.05). After treatment, the folic acid and vitamin B12 in the observation group showed no significant difference compared with the control group (P> 0.05). The folic acid and vitamin B12 significantly increased after treatment, with significant difference (P <0.05). Conclusion Hcy levels in patients with cerebral infarction were significantly higher than the control group, folic acid, vitamin B12 treatment can help reduce the level of Hcy, thereby improving the prognosis of cerebral infarction.