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目的：：观察中药消痤汤内服联合0.025%维A酸外用治疗寻常性痤疮的临床疗效及安全性。方法：86例寻常性痤疮患者随机分为观察组和对照组各43例,观察组采用中药消痤汤煎服,1剂/d,对照组口服琥乙红霉素0.25 g,tid；两组均每晚1次用0.025%维A酸乳膏外涂,疗程6周。比较两组疗效与药品不良反应。结果：观察组和对照组愈显率分别为69.77%和41.86%,差异有统计学意义(P<0.01)；总有效率分别为88.37%和69.77%,差异有统计学意义(P0.05),两组均未发生严重不良反应。结论：中药消痤汤内服联合0.025%维A酸外用治疗寻常性痤疮有较好的临床疗效,安全性好。“,”Objective:To observe the clinical efficacy and safety of traditional Chinese medicine Xiaozuo decoction combined with 0. 025% vitamin A for external use in the treatment of acne vulgaris. Methods:Totally 86 patients with acne vulgaris were randomly di-vided into the treatment group and the control group with 43 ones in each. The treatment group was treated with Xiaocuo dcoction, 1 dose/day, and the control group was orally treated with erythromycin ethylsuccinate, 0. 25g per time, 3 times per day. The treatment course was 6 weeks, and both groups were treated with 0. 025% tretinoin cream once every night. The clinical efficacy and adverse drug reactions were compared between the two groups. Results:The obvious effective rate of the treatment group and the control group was 69. 77% and 41. 86%, respectively, and the total effective rate was 88. 37% and 69. 77%, respectively. There was significant difference in the obvious effective rate between the two groups (P<0. 01), while there was significant difference in the total effective rate between the two groups (P0. 05). There were no serious adverse reactions in the two groups. Conclusion: Xiaocuo decoction combined with 0. 025% tretinoin in the treatment of acne vulgaris has promising clinical efficacy with high safety.