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建立了内皮素的放射免疫分析法，并用以观察了２２例慢性肾炎患者和１１例慢性肾衰患者血液透析前后免疫活性内皮素（ｉｒ－ＥＴ）的动态变化。结果表明慢性肾炎及慢性肾衰患者血浆ＥＴ含量均显著增高（Ｐ＜０．０１），但后者更明显；血透后血浆ＥＴ含量显著降低（Ｐ＜０．０５），但但仍高于对照组；透析过程中，血液通过透析器前后ＥＴ含量不变，透析液中ＥＴ含量极低，表明血浆ＥＴ不能从透析液中滤出。结果提示ＥＴ可能是一种促慢性肾炎恶化的因子。
A radioimmunoassay of endothelin was established and used to observe the dynamic changes of ir-ET before and after hemodialysis in 22 chronic nephritis patients and 11 chronic renal failure patients. The results showed that the levels of plasma ET in patients with chronic nephritis and chronic renal failure were significantly increased (P <0.01), but the latter were more obvious. The ET content in plasma after hemodialysis was significantly decreased (P <0.05) In the control group, during dialysis, the content of ET in the dialysis fluid remained unchanged after the blood passed through the dialyzer, indicating that the plasma ET could not be filtered out of the dialysis fluid. The results suggest that ET may be a factor that aggravates chronic glomerulonephritis.