通常在α-干扰素治疗有效的慢性肝炎患者的血清中,用PCR方法测不到HCV RNA,但常有生化方面的异常,并伴HCV病毒血症的复发,提示病毒并未被完全清除。本文旨在确定:1.肝内HCV RNA被清除可否预示为一种持久有效(SR);2.周围血单个核细胞(PBMC)中HCV RNA持续阳性能否预示为以前完全有效(CR)的病人又有复发。 α-IFN治疗结束后,即确定17例慢性肝炎病人肝内有HCV RNA,其中13例为CR,4例为无效(NR);13例CR者中10例PBMC的HCV RNA HCV RNA is usually undetectable in the sera of patients with chronic hepatitis treated with interferon-alpha (IFN), but often has biochemical abnormalities associated with the recurrence of HCV viremia, suggesting that the virus has not been completely eliminated. The purpose of this paper is to determine: 1. Whether HCV RNA is cleared in the liver can predict a long-lasting effect (SR); 2. Whether persistent positive HCV RNA in peripheral blood mononuclear cells (PBMCs) predicts a previous complete response (CR) The patient has a recurrence. After the treatment of α-IFN, 17 HCV RNA was identified in the liver of the patients with chronic hepatitis, of which 13 were CR and 4 were inactive (NR). Of 13 CR patients, 10