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为比较卡铂多相脂质体、乳剂和水剂在腹膜后淋巴结中铂的浓度，将卡铂的３种剂型（各含卡铂３０ｍｇ／６ｍｌ）分别腹腔注射于３组家兔，定时采集静脉血、剖腹取腹腔组织和腹膜后淋巴结，以原子吸收分光光度计测定铂含量。结果：脂质体组腹膜后淋巴结中铂峰浓度比水剂组高近３倍，药－时曲线下面积显著高于乳剂组和水剂组。腹腔组织铂浓度脂质体组与水剂组无显著差别，但血清铂浓度明显低于乳剂组和水剂组。此项研究对提高卵巢恶性肿瘤化疗的疗效和减少副作用有重要的理论意义。
To compare the concentration of platinum in the retroperitoneal lymph nodes of carboplatin multiphasic liposomes, emulsions and aqueous preparations, three dosage forms of carboplatin (each containing carboplatin 30mg / 6ml) were intraperitoneally injected into three groups of rabbits and collected regularly Venous blood, celiotomy and retroperitoneal lymph node dissection were performed to determine the content of platinum by atomic absorption spectrophotometer. Results: The peak area of platinum peak in retroperitoneal lymph node of liposome group was nearly 3 times higher than that of water solution group. The area under the curve of drug - time curve was significantly higher than that of emulsion group and water solution group. Intraperitoneal platinum concentration liposome group and water group no significant difference, but the serum concentration of platinum was significantly lower than the emulsion group and the liquid group. The study of ovarian cancer chemotherapy to improve the efficacy and reduce side effects have important theoretical significance.