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用放射免疫法测定３８例分泌性中耳炎患者的血清和中耳积液中肿瘤坏死因子（ＴＮＦ）的浓度，结果显示：①分泌性中耳炎患者血清ＴＮＦ浓度高于正常人对照组（Ｐ＜０．０１）。②中耳积液ＴＮＦ浓度明显高于血清ＴＮＦ含量（Ｐ＜０．００１）。③分泌性中耳炎慢性组中耳积液ＴＮＦ浓度高于急性组（Ｐ＜０．００１）。提示分泌性中耳炎积液中ＴＮＦ可能主要由中耳粘膜局部产生，在分泌性中耳炎炎症反应中起免疫抑制作用。中耳积液中高浓度的ＴＮＦ可能是慢性分泌性中耳炎经久不愈的一个因素。
The levels of TNF in the serum and middle ear effusion of 38 patients with secretory otitis media were determined by radioimmunoassay. The results showed that: ① The serum TNF concentration of patients with secretory otitis media was higher than that of the control group (P <0. 01). ② TNF concentration in middle ear effusion was significantly higher than that in serum TNF (P <0.001). ③ secretion of otitis media middle ear effusion TNF concentration was higher than the acute group (P <0.001). Tip TNF in secretory otitis media effusion may be mainly produced by the middle ear mucosa, play an immunosuppressive role in the inflammatory response of secretory otitis media. High concentrations of TNF in the middle ear effusion may be a factor in the chronic unhealed otitis media.