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肺结核至今仍是世界上常见的疾病之一,合理的化疗是防治措施的一个关键。以往沿用的标准化疗,常由于疗程太长,患者不能长期坚持服药或因抗药菌株的出现而达不到理想的疗效。为了克服这些缺点,几年来胸内科医生选用了几种强有力的、灭菌速度快而毒性又低的药物,在全程监督下(每次在医务人员面前一次吞服所规定的药物,如有漏服即追寻补服并对门诊病人定期随访)联合使用,既减少了抗药菌株的出现又可能把疗程从1～2年缩短到6～9个月,在习惯上称为短程化疗。本文报导笔者1983年2月至1985年2月在南部非洲博茨瓦纳工作期间收治的,用短程化疗治疗的活动性肺结核病人102例的结果。
Tuberculosis is still one of the most common diseases in the world. Reasonable chemotherapy is a key to prevention and treatment. The standard chemotherapy used in the past is often due to a long course of treatment. Patients cannot adhere to the medication for a long period of time or may not achieve the desired therapeutic effect due to the emergence of resistant strains. In order to overcome these shortcomings, several years have seen the use of powerful, rapidly sterilized and low-toxic drugs by physicians who are in full surveillance (once swallowed once in front of medical personnel, if any Leakage service, which is to seek for supplementation and regular follow-up of outpatients, is used in combination to reduce the emergence of drug-resistant strains and may shorten the course of treatment from 1 to 2 years to 6 to 9 months. It is customarily called short-course chemotherapy. This article reports the results of 102 patients with active tuberculosis who were treated with short-course chemotherapy during the period from February 1983 to February 1985 in Botswana, southern Africa.