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采用亚慢性动物实验的方法,氟砷联合作用对肝、肾的损伤进行了专题研究。研究结果表明:氟砷联合作用对肝、肾 SOD、GSH-Px 酶活性和-SH 含量均有影响。氟与砷之间存在着拮抗作用。对肝组织 Zn、Fe、Ca、Mg 及肾组织 Mg、Ca、Sr、Al 的影响也属于拮抗作用。对肾脏 Fe 有明显蓄积作用,但对肾脏 Mn 的影响属协同作用。提示氟砷联合作用对肝、肾的损伤,一方面是氟和砷的直接作用,另一方面是氟砷通过影响肝、肾组织酶活性而引起自由基平衡紊乱及无机元素紊乱而造成损伤。尽管氟砷联合作用在对肝脏、肾脏多项指标影响方面呈拮抗作用,而这种拮抗作用也是通过组织细胞的代谢活动来体现的,因此不可避免地要影响组织细胞正常代谢活动而造成肝脏和肾脏的损伤。
Subchronic animal experiments using the method of fluoride and arsenic combined effects of liver and kidney damage were a special study. The results showed that the combination of fluoride and arsenic had effects on the activity of SOD, GSH-Px and the content of -SH in liver and kidney. There is antagonism between fluoride and arsenic. The effects of Zn, Fe, Ca, Mg and Mg, Ca, Sr and Al in renal tissue also belong to antagonistic effect. Significant accumulation of Fe on the kidneys, but the impact of renal Mn is a synergistic effect. It is suggested that the combined effect of fluoride and arsenic on the liver and kidney damage, on the one hand the direct effect of fluorine and arsenic, on the other hand, fluorine and arsenic caused by liver and kidney enzyme activity caused by free radical balance disorders and inorganic elements caused by damage. Although the combination of fluoride and arsenic in the liver, kidney a number of indicators of the impact of antagonism, and this antagonism is also reflected by the metabolic activity of tissue cells, it is inevitable to affect the normal metabolism of tissue cells and liver and Kidney damage.