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近年,骨髓移植不断取得成就。但移植后严重的复合免疫不全症、移植物抗宿主病(GVHD)、间质性肺炎以及由病毒或细菌引起的严重感染性疾病等,还有待今后研究解决。本文简述骨髓移植在治疗再生障碍性贫血(“再障”)和急性白血病中,目前存在的问题及展望。骨髓移植的适应症,除再障以外,还有严重复合免疫不全症、急性白血病、骨硬化病、Wiscott-Aldrich综合征等。患有这些疾病的患者,如有主要组织相容性抗原(MHC)相一致的同胞者,应考虑用骨髓移植治疗。最近美
In recent years, bone marrow transplantation continue to make achievements. However, severe combined immunodeficiency syndrome, graft-versus-host disease (GVHD), interstitial pneumonia, and severe infectious diseases caused by viruses or bacteria after transplantation have yet to be studied and solved in the future. This article describes the current problems and perspectives of bone marrow transplantation in the treatment of aplastic anemia (“aplastic anemia”) and acute leukemia. Bone marrow transplantation indications, in addition to aplastic anemia, there are severe combined immunodeficiency syndrome, acute leukemia, osteopetrosis, Wiscott-Aldrich syndrome. Patients with these conditions should be considered for bone marrow transplantation if their siblings are compatible with major histocompatibility antigens (MHC). Recently beauty