用多波长数据线性回归法和正交函数分光光度法,不经分离直接测定复方新诺明片中磺胺甲基异恶唑(SMZ)和甲氧苄氨嘧啶(TMP)的含量。本法方法简单,操作迅速。磺胺甲基异恶唑的平均回收率为99.72—100.5％,变异系数小于0.48％,甲氧苄氨嘧啶的平均回收率为99.25—99.46％,变异系数小于0.83％。其准确度和精密度能满足制剂分析的要求。 The contents of Sulfamethoxazole (SMZ) and Trimethoprim (SMP) in cotrimoxetine tablets were determined directly without separation by multiple wavelength data linear regression and orthogonal function spectrophotometry. The method is simple and quick to operate. The average recovery of sulfamethoxazole was 99.72-100.5%, the coefficient of variation was less than 0.48%, the average recovery rate of trimethoprim was 99.25-99.46%, and the coefficient of variation was less than 0.83%. Its accuracy and precision can meet the requirements of formulation analysis.