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目的:探索中西医结合治疗 MDS的新途径。方法:将MDS—RAEB(RAEB—T)48例随机分为中西医结合组 38例(RAEB28例,RAEB—T10例)和对照组 10例(RAEB6例,RAEB—T4例)。中西医结合组用再障生血片及天赐丸口服,并联合小剂量Ara—c静滴或肌注。时照组仅单用 Ara—c治疗。结果:中西医结合组总有效率 73.6%,对照组总有效率50.0%,两组有显著性差异(P<0.05)。结论:再障生血片及天赐丸不仅能增强扶正功能,提高免疫力,而且有提高抑制、杀伤病变白细胞的能力。联合Ara—c 更能提高疗效,减轻Ara—c的毒副作用。
Objective: To explore a new way to treat MDS with integrated traditional Chinese and western medicine. Methods: Forty-eight cases of MDS-RAEB (RAEB-T) were randomly divided into two groups: 38 cases of RAEB-T10 (RAEB-T10 cases) and 10 cases of control group (RAEB-T4 cases). Integrative Medicine group with aplastic anemia tablets and Tianci pills oral, combined with low-dose Ara-c intravenous infusion or intramuscular injection. Shizhao group only with Ara-c treatment. Results: The total effective rate of TCM-WM combination group was 73.6%, while that of control group was 50.0%. There was significant difference between the two groups (P <0.05). Conclusion: Aplastic Sputum and Tianci Wan can not only enhance righting and strengthening function, improve immunity, but also improve the ability of inhibiting and killing diseased leukocytes. Combination of Ara-c can improve the efficacy and reduce the toxic side effects of Ara-c.