目的:观察胃溃疡患者预后与幽门螺杆菌感染的关系。方法:选取我院112例消化性溃疡患者,随机分为观察组和对照组,各56例。对观察组患者给予根除幽门螺杆菌治疗,给予对照组患者常规抑酸治疗。8周后,对2组疗效进行比较。所有患者均随访6个月,并对治疗有效患者的复发情况做统计分析。结果:观察组总有效率为87.5%,对照组为89.3%,二者比较差异不明显(x2=0.087,P=0.7680);观察组复发率为5.4%,对照组为34.0%。2组有显著性差异(x2=14.481,P=0.0001)。结论:幽门螺杆菌感染可显著增加胃溃疡患者的复发率,影响患者预后,根除幽门螺杆菌可显著降低胃溃疡的复发率。 Objective: To observe the relationship between the prognosis of gastric ulcer and Helicobacter pylori infection. Methods: A total of 112 patients with peptic ulcer in our hospital were randomly divided into observation group and control group, with 56 cases in each group. Patients in the observation group were given eradication of Helicobacter pylori, and patients in the control group were given conventional acid-suppressing therapy. After 8 weeks, the two groups were compared. All patients were followed up for 6 months, and the recurrence of patients with effective treatment for statistical analysis. Results: The total effective rate was 87.5% in the observation group and 89.3% in the control group, with no significant difference between the two groups (χ2 = 0.087, P = 0.7680). The recurrence rate was 5.4% in the observation group and 34.0% in the control group. There was a significant difference between the two groups (x2 = 14.481, P = 0.0001). Conclusion: Helicobacter pylori infection can significantly increase the recurrence rate of patients with gastric ulcer, affecting the prognosis of patients, eradication of Helicobacter pylori can significantly reduce the recurrence rate of gastric ulcer.