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1％利凡诺注射液在临床上用于引产成功率高,是近年来开展计划生育的重要药剂。但由于利凡诺注射液(按广东省制剂规范生产)的不稳定性(颜色逐渐变深),使用周期短(两个月内),毒性增加,往往造成我们在制剂上的困难。为了计划生育工作顺利进行,提高药品质量,降低毒性,我们采取5～10℃存放的做法,得到较满意的效果。根据利凡诺在波长362nm处有最大吸收,用紫外分光光度法与其它方法对利凡诺不稳定性的检测进行实验性探讨。一、标准溶液的配制与最大吸收峰的确定精密称取在105℃干燥至恒重的利凡诺100mg,置100ml容量瓶中,用蒸馏水稀释至刻度,摇匀。在上标准溶液中精密吸取1ml置100ml容量瓶中,加蒸馏水至刻度,摇匀。以蒸馏水为空白,用uv-240紫外
1% Rivanol injection clinically used for induction of labor with high success rate, is an important agent for family planning in recent years. However, due to the instability (gradual darkening) of Rivanol Injection (manufactured according to the Guangdong preparation specification), the short period of use (within two months) and the increased toxicity often cause difficulties in formulation. In order to carry out family planning work smoothly, improve drug quality, reduce toxicity, we take the practice of 5 ~ 10 ℃ storage, get more satisfactory results. According to rivanol at the wavelength of 362nm maximum absorption, UV spectrophotometry and other methods for the rivarino instability of the experimental study. First, the standard solution of the preparation and determination of the maximum absorption peak Weigh accurately dried at 105 ℃ to constant weight Rivanol 100mg, set 100ml volumetric flask, diluted with distilled water to the mark, shake. In the standard solution on the precision draw 1ml 100ml volumetric flask, add distilled water to the mark, shake. To distilled water blank, uv-240 UV