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目的:总结输卵管癌的临床特征,探讨影响输卵管癌复发与生存的因素。方法:回顾分析2001年1月至2011年5月黑龙江省肿瘤医院收治的52例原发性输卵管癌患者的临床资料,采用Cox风险比例回归模型进行生存分析。结果:52例患者的复发率为59.6%(31/52),生存率为42.3%(22/52)。单因素分析显示,FIGO分期、CA125值、组织分级、残余病灶大小与输卵管癌的复发和生存预后有关。多因素分析显示,FIGO分期、CA125值、组织分级、残余病灶大小是影响输卵管癌复发的重要因素,FIGO分期、CA125值、残余病灶大小是影响患者生存预后的重要因素。结论:FIGO分期晚、术前CA125高、组织分化差、残余病灶大的患者复发的风险大;FIGO分期晚、术前CA125高、残余病灶大的患者预后差。对于有上述危险因素的患者应加强随访,及时给予干预治疗,从而提高患者术后生存期,改善患者生存质量。
OBJECTIVE: To summarize the clinical features of fallopian tube cancer and to explore the factors affecting the recurrence and survival of fallopian tube cancer. Methods: The clinical data of 52 patients with primary fallopian tube cancer admitted to Heilongjiang Provincial Tumor Hospital from January 2001 to May 2011 were retrospectively analyzed. Survival analysis was performed by Cox risk proportional regression model. Results: The recurrence rate of 52 patients was 59.6% (31/52) and the survival rate was 42.3% (22/52). Univariate analysis showed that FIGO staging, CA125 value, histological grade and remnant lesion size were related to the recurrence and prognosis of fallopian tube carcinoma. Multivariate analysis showed that FIGO staging, CA125 value, histological grade and residual lesion size were the important factors influencing the recurrence of fallopian tube cancer. FIGO staging, CA125 value and residual lesion size were the important factors influencing survival and prognosis of patients. Conclusion: There is a high risk of recurrence in patients with FIGO staging, high preoperative CA125, poor tissue differentiation and large residual remnant. In patients with FIGO staging, the patients with high CA125 preoperative and high residual remnant lesions have a poor prognosis. For patients with the above risk factors should be strengthened follow-up, timely intervention to improve postoperative survival and improve patient quality of life.