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目的:观察服用小剂量磷酸二酯酶-5(PDE5)抑制剂他达那非对动脉性勃起功能障碍(ED)患者的疗效。方法:对43例动脉性ED患者采用了疗程为4周的隔日小剂量(5 mg)晚餐后口服他达那非的用药方案,在治疗前后进行IIEF-5评分同时用彩色多普勒超声联合阴茎血管活性药物前列腺素(PGE-1)注射实验,检测阴茎双侧海绵体动脉的收缩期最大流速(PSV)。结果:经统计学分析,IIEF-5评分以及阴茎双侧海绵体动脉的PSV在治疗4周后有显著提高(P<0.05)。结论:口服小剂量他达那非能有效提高动脉性ED患者阴茎海绵体动脉的收缩期最大流速,改善患者的勃起质量。
Objective: To observe the effect of low dose of phosphodiesterase-5 (PDE5) inhibitor tadalafil on patients with arterial erectile dysfunction (ED). METHODS: A total of 43 patients with arterial ED were enrolled in a four-week, low-dose (5 mg) dose of tadalafil after a four-week dosing. IIEF-5 scores were assessed before and after treatment with color Doppler ultrasound Penile vasoactive prostaglandin (PGE-1) injection test was performed to detect the maximum systolic velocity (PSV) of penis cavernous arteries. Results: According to the statistical analysis, the IIEF-5 score and the PSV of penis cavernous arteries were significantly increased after 4 weeks of treatment (P <0.05). Conclusion: Oral low dose of tadalafil can effectively increase the maximum systolic velocity of arterial ED patients and improve the erectile quality of patients.