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目的:探究替吉奥联合健脾丸对老年结直肠癌转移患者血清肿瘤标志物、环氧合酶-2(COX-2)及基质金属蛋白酶-2(MMP-2)水平影响。方法:收集肛肠科病房患者51例,采用随机数字分配法,随机分为治疗组27例与对照组24例,两组均采用替吉奥治疗,治疗组在此基础上服用健脾丸,治疗结束后检测对比疗效、患者血清肿瘤标志物、COX-2、MMP-2水平,以及随访中不良反应情况。结果:研究结果显示,治疗后两组肿瘤标志物CEA、CA199以及CA242水平下降(P<0.05),COX-2水平上升,MMP-2水平下降(P<0.05);与对照组相比CEA、CA199以及CA242水平较低(P<0.05),COX-2水平较高(P<0.05),MMP-2水平较低(P<0.05),消化道反应以及骨髓抑制发生率较低(P<0.05),总有效率较高(P<0.05)。结论:替吉奥联合健脾丸治疗老年结直肠癌转移患者,能有效降低癌细胞活性,抑制肿瘤细胞生长转移,缓解病情,安全性高。
Objective: To investigate the effect of tegaserod combined with spleen-qi pill on serum tumor markers, cyclooxygenase-2 (COX-2) and matrix metalloproteinase-2 (MMP-2) in elderly patients with metastasis of colorectal cancer. Methods: A total of 51 patients with anorectal ward were collected and randomly divided into treatment group (n = 27) and control group (n = 24). The two groups were treated with TIGO. The treatment group took Jianpi Pill for treatment At the end of the experiment, the curative effect, serum tumor markers, COX-2, MMP-2 levels and the adverse reactions during follow-up were tested. Results: The results showed that the levels of tumor markers CEA, CA199 and CA242 decreased (P <0.05), the levels of COX-2 increased and the levels of MMP-2 decreased (P <0.05) CA199 and CA242 levels were lower (P <0.05), COX-2 levels were higher (P <0.05), MMP-2 was lower (P <0.05), and the incidence of digestive tract reaction and myelosuppression was lower ), The total effective rate is higher (P <0.05). Conclusion: Treatment of elderly patients with colorectal cancer with TIGO combined with Jianpi Pill can effectively reduce the activity of cancer cells, inhibit the growth and metastasis of tumor cells, relieve the disease and have high safety.