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OK-432为溶血性链球菌制剂,除有直接抗肿瘤作用外也有赋活宿主免疫力和防止白细胞减少的作用,近年来用于头颈部恶性肿瘤的治疗,收到了效果。作者们自1977年3月至1978年5月用OK-432治疗头颈部恶性肿瘤16例,男10,女5;年龄31～79岁。包括喉癌4例,上颌窦癌2例,下咽部癌2例,鼻咽癌、咽部癌、颌下腺癌、腮腺癌、舌癌、口底癌及上颌窦恶性黑瘤各1例。病理组织学为:鳞状上皮癌11例,腺癌2例,移行上皮癌1例,恶性黑瘤1例。其用法为:OK-432(picibsnil)由0.2KE(家兔单位)开始,逐渐增量至每次5KE。多数病例为每周给药3次,均为肌注。在15例中,14例并用~(60)Co照
OK-432 is a hemolytic streptococcus preparation that has the effect of activating the host immune system and preventing leukopenia in addition to its direct anti-tumor effect. In recent years, it has been used for the treatment of head and neck malignancies and has received results. The authors used OK-432 to treat 16 cases of head and neck malignancy from March 1977 to May 1978, male 10 and female 5; aged 31 to 79 years old. Including 4 cases of laryngeal cancer, 2 cases of maxillary sinus cancer, 2 cases of hypopharyngeal cancer, nasopharyngeal cancer, pharynx cancer, submandibular gland cancer, salivary gland cancer, tongue cancer, floor cancer and maxillary sinus malignant melanoma in 1 case each. Histopathology included 11 cases of squamous cell carcinoma, 2 cases of adenocarcinoma, 1 case of transitional epithelial carcinoma, and 1 case of malignant melanoma. Its usage is: OK-432 (picibsnil) starts from 0.2KE (rabbit unit) and gradually increases to 5KE each time. Most cases are administered 3 times per week and are intramuscular injections. In 15 cases, 14 cases were treated with ~(60)Co