目的：观察吗啡对胸腺细胞ＣＤ４，ＣＤ８细胞周期增殖、ＩＬ２的影响及人参四物汤对其调节作用。方法：小剂量递增给药建立吗啡成瘾动物模型后，采用流式细胞仪分析各组小鼠胸腺ＣＤ４、ＣＤ８细胞ＤＮＡ含量、增殖指数以及ＩＬ２Ｒ的情况。结果：吗啡成瘾组小鼠ＣＤ４、ＣＤ８细胞Ｓ，Ｇ２＋Ｍ期和增殖指数显著低于正常组和人参四物汤组动物，而Ｇ０／Ｇ１期高于后二者；吗啡依赖小鼠ＩＬ２Ｒ表达下降，人参四物汤组动物的Ｔ细胞表面ＩＬ２Ｒ表达有明显增加。结论：吗啡使胸腺细胞ＤＮＡ复制受阻导致功能细胞减少，ＩＬ２Ｒ表达下降，人参四物汤可对抗吗啡的上述作用 Objective: To observe the effects of morphine on cell cycle proliferation and IL2 of thymocytes in CD4 and CD8 and the regulatory effect of ginseng siwu decoction. METHODS: After establishing an animal model of morphine addiction with low-dose incremental administration, flow cytometry was used to analyze the DNA content, proliferation index, and IL 2R of thymus CD4 and CD8 cells in each group. Results: The levels of S and G2+M and proliferation index of CD4 and CD8 cells in morphine addiction group were significantly lower than those in normal group and Ginseng Siwutang group, but the G0/G1 phase was higher than the latter two; morphine dependent mice IL-2R The expression decreased, and the expression of IL-2R on the surface of T cells in Renshen Siwu Tang group was significantly increased. CONCLUSION: Morphine inhibits the replication of thymocyte DNA and results in the reduction of functional cells and the expression of IL-2R. The effect of ginseng Siwu Decoction against morphine