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目的 初步探讨肿瘤坏死因子 (TNF α)含量与癌症恶病质的关系。方法 用苯丙酸诺龙及营养支持疗法对 19例恶病质患者治疗三周 ,观察治疗前后患者血清中TNF α ,体重、右上臂中部周径、三头肌皮摺厚度 ,KPS评分、总蛋白、白蛋白的变化 ,并与 17例健康对照组进行比较。结果 疾病组治疗前TNF α值明显高于对照组 (P <0 0 1) ,治疗后TNF α值较治疗前明显下降 (P <0 0 1) ,并接近对照组 ,治疗后其余各项指标较治疗前均增加 ,病情好转时TNF α值是下降的。结论 TNF α可能是参与恶病质过程的重要细胞因子之一 ,其水平高低与病情轻重相关联
Objective To explore the relationship between tumor necrosis factor (TNF α) content and cancer cachexia. Methods Nineteen patients with cachexia were treated with nandrolone phenylpropionate and nutritional support therapy for three weeks. The serum TNFα, body weight, central diameter of the right upper arm, triceps skin fold thickness, KPS score, total protein, and serum were measured before and after treatment. Changes in albumin were compared with 17 healthy controls. Results The TNF α value in the disease group before treatment was significantly higher than that in the control group (P <0 01). The TNF α value after treatment was significantly lower than before treatment (P <0 01), and it was close to the control group. The remaining indicators after treatment Compared with before treatment, the TNF α value decreased when the condition improved. Conclusion TNF α may be one of the important cytokines involved in the cachexia process, and its level is related to the severity of the disease.