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目的探讨结肠直肠癌肝转移的诊疗方法及影响其预后的因素。方法回顾性分析我院1991年1月~2006年1月收治的113例结肠直肠癌肝转移病人的临床资料。结果全组总的1、3、5年生存率分别为91.6%、34.3%和23.1%。同时性肝转移病人的生存率明显高于异时性肝转移病人(P<0.01)。同时性肝转移病人Ⅰ期手术和Ⅱ期手术的生存率无显著性差异(P>0.05)。肝转移瘤最大直径>5cm者的5年生存率较最大直径≤5cm者低,两者有显著性差异(P<0.05)。结论外科手术是结肠直肠癌肝转移的首选治疗方法,新辅助化疗已成为术前准备的一部分。
Objective To investigate the diagnosis and treatment of colorectal cancer with liver metastasis and its prognostic factors. Methods The clinical data of 113 patients with liver metastases from colorectal cancer admitted from January 1991 to January 2006 in our hospital were retrospectively analyzed. Results The overall 1, 3, 5-year overall survival rates were 91.6%, 34.3% and 23.1% respectively. The survival rate of patients with simultaneous liver metastasis was significantly higher than that of patients with heterotopic liver metastasis (P <0.01). There was no significant difference in survival between patients with stage Ⅰ and stage Ⅱ liver metastases (P> 0.05). The 5-year survival rate of patients with liver metastases> 5cm in diameter was significantly lower than those with the largest diameter ≤5cm (P <0.05). Conclusion Surgery is the first choice of treatment of liver metastases of colorectal cancer. Neoadjuvant chemotherapy has become a part of preoperative preparation.