以前的实验证明 ,在应激条件下 ,外周淋巴组织中可产生一种蛋白质 ,具有抑制某些免疫功能的作用 ,称为应激免疫抑制蛋白 (immunesuppressiveproteinofstress,ISPS)。本实验用人外周淋巴器官扁桃体进行了研究 ,证明扁桃体的提取物能抑制小鼠由ConA诱导的淋巴细胞转化 ,而且这种抑制作用可被ISPS单克隆抗体 (2C4 )部分翻转。间接ELISA法证明人扁桃体提取物能与 2C4单克隆抗体相结合。以ISPS单克隆抗体 (2C4 )作免疫组织化学研究 ,证明人扁桃体中有很多染色呈阳性的细胞。这些结果从不同角度提示 ,人外周淋巴组织中存在一种与ISPS相类似的免疫抑制物质 Previous experiments show that under stress conditions, peripheral lymphoid tissue can produce a protein that has the function of inhibiting certain immune functions, called the stress immunosuppressive protein (ISPS). In this study, human peripheral lymphoid organ tonsils were studied to demonstrate that tonsil extract can inhibit ConA-induced lymphocyte transformation in mice and that this suppressive effect can be partially reversed by ISPS monoclonal antibody (2C4). Indirect ELISA demonstrated that human tonsil extract binds to 2C4 monoclonal antibody. ISPS monoclonal antibody (2C4) for immunohistochemistry to prove that there are many human tonsil staining positive cells. These results suggest from different perspectives that there is an immunosuppressive substance similar to ISPS in human peripheral lymphoid tissue