钙调神经磷酸酶和丝裂素活化蛋白激酶信号系统是调节心肌肥厚发生和发展的两条重要细胞信号通道;前者在体内病理因素刺激下活性增高而导致心肌肥厚形成,后者的3个成员胞外信号调节激酶、应激活化蛋白激酶和P38丝裂素活化蛋白激酶,在调节心肌肥厚中的作用则不同。另外,两者之间并不是孤立的,而是彼此交叉、互相协调、共同调节心肌肥厚反应。 Calcineurin and mitogen-activated protein kinase signaling are two important cellular signaling pathways that regulate the development and progression of cardiac hypertrophy. The former is activated by pathological factors and leads to cardiac hypertrophy. The latter three members Extracellular signal-regulated kinases, stress-activated protein kinases and P38 mitogen-activated protein kinases play a role in regulating cardiac hypertrophy. In addition, the two are not isolated, but rather cross each other and coordinate with each other to jointly regulate cardiac hypertrophy.