头孢菌素类已越来越广泛地应用于创伤病人以预防感染,但由于这类病人因输血、补液、麻醉等原因使其血液动力学有所不同,导致药物的分布代谢均不同,这就意味着抗生素治疗的失败可能不是与药物有关而是与剂量有关.但迄今为止,还无任何关于抗生素在严重创伤病人体内的药代动力学资料,本次研究的目的就是为了揭示头孢唑肟在急诊剖腹术后的创伤病人体内的药代动力学以及血药浓度与病人疗效的关系. Cephalosporins have been used more and more widely in trauma patients to prevent infection, but due to blood transfusion, rehydration, anesthesia and other reasons to make their hemodynamics are different, resulting in the distribution of drug metabolism are different, which Means that the failure of antibiotic therapy may not be drug-related but dose-related, but so far there is no data on the pharmacokinetics of antibiotics in patients with severe trauma, the purpose of this study was to reveal that ceftizoxime Pharmacokinetics of trauma patients after emergency laparotomy as well as the relationship between plasma concentration and patient’s efficacy.