生长激素(GH)对免疫系统具有调节作用,但对T细胞功能的影响尚不清楚。CD_2为T淋巴细胞表面具有重要免疫功能的分子。本实验通过测定GH分泌过多患者外周血T细胞CD_2mRNA的表达,研究GH对T细胞功能的影响. 选择GH分泌过多患者(人GH口服葡萄糖抑制实验显示血清GH谷值>5.0μg/L)12例,其中男2例,女10例;年龄23～60岁(36.6±12.1,x±s,下同)。随机选择健康成人10名作为对照组,其中男5名,女5名;年龄21～26岁(24.4±2.2)。均于晨8时许空腹取外周血6ml.按Boyum氏聚蔗糖— Growth hormone (GH) has a regulatory effect on the immune system, but its effect on T cell function remains unclear. CD 2 is a molecule with important immune function on the surface of T lymphocytes. In this study, we examined the effect of GH on T cell function by measuring the expression of CD_2mRNA in peripheral blood T cells of patients with hypersecretion of GH.Selecting patients with hypersecretion of GH (serum GH trough GH> 5.0μg / L by human GH oral glucose inhibition test) 12 cases, including 2 males and 10 females; aged from 23 to 60 years (36.6 ± 12.1, x ± s, the same below). 10 healthy adults were randomly selected as the control group, including 5 males and 5 females; aged 21 to 26 years old (24.4 ± 2.2). 8:00 in the morning to take peripheral blood 6ml fasting by Boyum’s Ficoll -