论文部分内容阅读
目的观察单硝酸异山梨酯缓释片联合复方丹参滴丸治疗老年不稳定心绞痛的临床疗效。方法将老年不稳定心绞痛患者85例采用随机数字法分为观察组43例和对照组42例,观察组给予单硝酸异山梨酯缓释片联合复方丹参滴丸治疗,对照组予以单硝酸异山梨酯缓释片治疗。对比观察2组患者的临床疗效、血液黏度变化情况。结果观察组总有效率为93.0%高于对照组的71.4%,差异具有统计学意义(χ~2=6.23,P=0.02)。治疗前2组患者血液黏度各项指标比较差异无统计学意义(P>0.05)。治疗后2组患者全血高切黏度、全血低切黏度、血细胞比容均降低,且观察组降低幅度大于对照组,差异均有统计学意义(P<0.05)。2组患者不良反应发生率比较差异无统计学意义(P<0.05)。结论单硝酸异山梨酯缓释片联合复方丹参滴丸治疗老年不稳定心绞痛临床疗效好,应用价值高,值得在临床实践中推广应用。
Objective To observe the clinical efficacy of isosorbide mononitrate sustained-release tablets combined with compound danshen dropping pills in the treatment of unstable angina pectoris in the elderly. Methods A total of 85 elderly patients with unstable angina were divided into observation group (n = 43) and control group (n = 42) by random number method. The observation group was given isosorbide mononitrate sustained-release tablets combined with compound Danshen dropping pills, while the control group was given isosorbide mononitrate Ester release tablets treatment. Compare the clinical efficacy of two groups of patients, blood viscosity changes. Results The total effective rate in the observation group was 93.0%, which was significantly higher than that in the control group (χ ~ 2 = 6.23, P = 0.02). There was no significant difference in the indexes of blood viscosity between the two groups before treatment (P> 0.05). After treatment, the high shear viscosity of whole blood, low shear viscosity of whole blood and hematocrit decreased in both groups, and the decrease in observation group was larger than that in control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P <0.05). Conclusion Isosorbide Mononitrate Sustained Release Tablets combined with Compound Danshen Dripping Pills in the treatment of unstable angina pectoris has good clinical curative effect and high application value, which is worth popularizing and applying in clinical practice.