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目的观察隔日1次口服地高辛0.125mg治疗老年慢性充血性心力衰竭(CHF)的临床疗效及安全性。方法将78例老年CHF患者,采用抽签法随机分为治疗组40例和对照组38例。对照组以常规抗心力衰竭药物治疗;治疗组在常规抗心力衰竭药物基础上给予隔日1次口服地高辛0.125mg。观察6个月后2组治疗总有效率与左室射血分数(LVEF)及洋地黄中毒发生情况。结果 2组治疗后LVEF均有增加,治疗组优于对照组(P<0.05);治疗组总有效率略高于对照组,但差异无统计学意义(95.0%vs78.9%,P>0.05)。治疗组无患者因发生洋地黄中毒退出观察、治疗。结论隔日小剂量地高辛治疗老年CHF安全、有效。
Objective To observe the clinical efficacy and safety of oral digoxin 0.125mg once every other day in elderly patients with chronic congestive heart failure (CHF). Methods Seventy-eight elderly CHF patients were randomly divided into treatment group (n = 40) and control group (n = 38) by random selection method. The control group was treated with conventional anti-heart failure drugs. The treatment group received 0.125 mg of oral digoxin once every other day on the basis of conventional anti-heart failure drugs. After 6 months, the total effective rate of treatment and left ventricular ejection fraction (LVEF) and digitalis poisoning were observed. Results The LVEF in both groups increased after treatment, and the treatment group was better than the control group (P <0.05). The total effective rate in the treatment group was slightly higher than that in the control group, but the difference was not statistically significant (95.0% vs 78.9%, P> 0.05 ). Patients in the treatment group without digitalis due to the emergence of observation and treatment. Conclusions Every other day, low-dose digoxin is safe and effective in elderly CHF.