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目的:观察比较中药扶正消瘤汤配合介入疗法(治疗组)与单纯介入疗法(对照组)治疗贲门癌的临床效果。方法:69例贲门癌患者随机分为两组,对照组36例,采用Seldinger技术经一侧股动脉穿刺插管,将导管选择至贲门区肿瘤供血动脉注入化疗药物。治疗组33例,在对照组的基础上加用中药扶正消瘤汤口服。结果:近期有效率治疗组69·7%,对照组63·6%,两组比较差异无显著性(P>0·05);治疗组卡氏评分下降不明显(P>0·05),对照组下降明显(P<0·05);治疗组消化道反应及白细胞减低的发生率明显低于对照组(P<0·05);带瘤生存时间比较治疗组亦明显优于对照组(P<0·05)。结论:中药扶正消瘤汤配合介入疗法用于疗贲门癌的治疗可明显改善患者的生活质量,减轻毒副反应,延长带瘤生存时间,优于单纯介入疗法。
Objective: To observe and compare the clinical effects of Fuzheng Xiaoyu Decoction combined with interventional therapy (treatment group) and simple interventional therapy (control group) in the treatment of cardia cancer. Methods: Sixty-nine patients with cardia cancer were randomly divided into two groups. The control group received 36 cases. Seldinger technique was used to inject the chemotherapeutic drugs through the femoral artery on the side of femoral artery. The treatment group of 33 cases, based on the control group plus traditional Chinese medicine Fuzheng Xiaoliu Tang oral. Results: The effective rate of the treatment group was 69.7% and that of the control group was 63.6%, there was no significant difference between the two groups (P> 0.05); the Karnofsky score of the treatment group did not decrease significantly (P> 0.05) (P <0.05). The incidence of digestive tract reaction and leukopenia in the treatment group was significantly lower than that in the control group (P <0.05). The survival time of tumor-bearing group was also significantly better than that of the control group P <0 · 05). Conclusion: Fuzheng Xiaoyu Decoction combined with interventional therapy for the treatment of cardia cancer can significantly improve the quality of life of patients, reduce the side effects and prolong the survival time of the tumor, which is better than the interventional therapy alone.