论文部分内容阅读
目的对老年白血病的临床特征、合理治疗及影响预后的危险因素进行探讨。方法结果支持性姑息治疗组5例,完全缓解率为0,小剂量化疗组19例,完全缓解率26.3%,标准剂量联合化疗组13例,完全缓解率38.5%。急性白血病标准剂量化疗组的完全缓解率和中位生存时间均高于姑息治疗组(P<0.05),小剂量化疗组的生存时间高于标准治疗组(P<0.05)。结论老年急性白血病对化疗的耐受性差,缓解率低,死亡率高。对于老年急性白血病不能过分强调治疗方案的强度及单纯追求完全缓解率,应根据患者的实际情况选择个体化的方案。
Objective To investigate the clinical features, rational treatment and prognosis of senile leukemia. Methods Results Supportive palliative treatment group of 5 patients, the complete remission rate was 0, 19 cases of low-dose chemotherapy group, complete remission rate of 26.3%, the standard dose combined with chemotherapy group of 13 patients, the complete remission rate was 38.5%. The complete remission rate and median survival time of the standard-dose chemotherapy group were higher than those of the palliative treatment group (P <0.05). The survival time of the low-dose chemotherapy group was higher than that of the standard treatment group (P <0.05). Conclusion Elderly acute leukemia is poorly tolerated with chemotherapy, with low remission rate and high mortality. For elderly patients with acute leukemia can not be too much emphasis on the strength of treatment options and the pursuit of complete remission rate, should be based on the actual situation of patients choose individualized program.