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目的:观察氨酚羟考酮治疗带状疱疹后遗神经痛(PHN)的疗效和安全性。方法:44例PHN患者随机分为氨酚羟考酮组(A组,n=22)和盐酸曲马朵组(B组,n=22),分别给予口服氨酚羟考酮片和盐酸曲马朵片治疗。观察治疗前后疼痛强度(PI)变化、疼痛缓解度(PAR)、镇痛有效率及不良反应。结果:两组服药后NRS评分均明显降低(P<0.05),但组间比较无显著差异(P>0.05);氨酚羟考酮组的镇痛显效率虽高于盐酸曲马朵组,但无统计学差异(P>0.05);两组药物的不良反应主要表现为头晕、嗜睡、恶心、呕吐,不良反应总发生率两组间比较无显著差异(P>0.05)。结论:氨酚羟考酮治疗PHN患者镇痛效果良好,安全可靠,是PHN止痛的有效措施之一。
Objective: To observe the efficacy and safety of oxycodone in treating postherpetic neuralgia (PHN). Methods: Forty-four patients with PHN were randomly divided into two groups: A group (n = 22) and tramadol hydrochloride group (n = 22) Horse film treatment. Changes of pain intensity (PI), pain relief (PAR), analgesic efficiency and adverse reactions were observed before and after treatment. Results: The NRS scores of the two groups were significantly decreased (P <0.05), but there was no significant difference between the two groups (P> 0.05). The analgesic efficiency of oxycodone group was higher than that of tramadol hydrochloride group, There was no significant difference between the two groups (P> 0.05). Adverse reactions of the two groups were mainly dizziness, drowsiness, nausea, vomiting, and the incidence of adverse reactions was no significant difference between the two groups (P> 0.05). CONCLUSION: Paracetamol and oxycodone are effective and safe in the treatment of PHN. It is one of the effective measures for analgesia of PHN.