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目的 评估Cockcroft Gault方程和MDRD方程计算肾小球滤过率来反应肾功能的可行性。方法 测定14 7名患者的2 4小时肌酐清除率(2 4hCcr) ,同时测定血肌酐、尿肌酐、白蛋白、尿素氮并称体重。用Cockcroft -Gault方程(CG -GFR)和MDRD方程(MD -GFR分别以白人和黑人计算)估算肾小球滤过率,并进行比较分析。结果 总体上,CG- GFR与2 4hCcr无差异,呈高相关(r =0 .879)。2 4hCcr分别与MD- GFR(白人)和MD GFR(黑人)比较,差异有统计学意义。结论 我国人群可以适用Cockcroft Gault方程来评估肾功能,值得在临床上推广应用。MDRD方程可能不适用于中国人。
Objective To evaluate the feasibility of calculating renal glomerular filtration rate (GFR) by Cockcroft Gault equation and MDRD equation. Methods The 24-hour creatinine clearance (14 hCcr) in 14 7 patients was measured. Serum creatinine, creatinine, albumin and urea nitrogen were measured at the same time and weighed. Glomerular filtration rates were estimated using the Cockcroft-Gault equation (CG-GFR) and the MDRD equation (MD-GFR in white and black, respectively) and compared. Overall, there was no significant difference between CG-GFR and 24 hCcr (r = 0.898). 2 4hCcr respectively with MD-GFR (white) and MD GFR (black), the difference was statistically significant. Conclusion Our population can apply Cockcroft Gault equation to evaluate renal function, which is worth popularizing in clinic. The MDRD equation may not apply to Chinese.