蛋白水解酶系统在恶性肿瘤的发生、扩展、转移过程中的作用研究，近年很受注意。因其作用底物是细胞外基质和结缔组织基质（防止肿瘤侵袭的天然屏障）蛋白。正常情况下，蛋白酶系统受制于可中和酶活性并保持组织屏障完整的蛋白（水解）酶抑制物。癌细胞能分泌大量蛋白酶并存在 The role of the proteolytic enzyme system in the development, progression and metastasis of malignant tumors has received much attention in recent years. Because of its role in the substrate is the extracellular matrix and connective tissue matrix (a natural barrier to prevent tumor invasion) protein. Under normal conditions, protease systems are restricted by protein (hydrolytic) enzyme inhibitors that neutralize enzyme activity and maintain the integrity of the tissue barrier. Cancer cells can secrete large amounts of proteases and exist