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TMA用于颜料、塑料等工业中,为一小分子量化学物质,它能引起人哮喘样综合征。用TMA真皮内致敏的豚鼠,豚鼠将产生哮喘样综合征的抗原刺激应答反应,包括立即的支气管缩小和延迟细胞浸润入肺,特别是嗜酸性细胞浸润。致敏的豚鼠产生TMA特异性IgG_1,这在该动物哮喘模型中被认为是十分重要的,但豚鼠也产生TMA特异IgG_2抗体。本文旨在确定IgG_1和IgG_2在TMA所引发的豚鼠急性支气管缩小和延迟性细胞浸润中的作用,采用气管内滴注TMA特异IgG_2(一种富含TMA
TMA is used in industries such as paints and plastics as a small molecular weight chemical that causes asthma-like syndrome in humans. With guinea pigs that are sensitized intradermally with TMA, guinea pigs will develop an antigenic stimulation response to asthma-like syndromes, including immediate bronchoconstriction and delayed cellular infiltration into the lungs, particularly eosinophil infiltration. The sensitized guinea pig produces TMA-specific IgG 1, which is considered as important in this animal model of asthma, but also produces TMA-specific IgG 2 antibodies in guinea pigs. This study aimed to determine the role of IgG_1 and IgG_2 in acute bronchoconstriction and delayed cell infiltration induced by TMA in guinea pigs. Endotracheal instillation of TMA-specific IgG_2 (a TMA-