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腺苷在肾脏中的不同作用方式是其具有调节大量生理功能能力的最好证据。腺苷与肾细胞膜上受体结合,则兴奋肾脏的各种生理反应,包括血流动力学、激素、神经递质的释放和肾小管再吸收的改变。由5′-磷酸腺苷水解、底物增加或酶还原生成的细胞外腺苷至少与细胞表面的二种受体结合,兴奋和抑制3′,5′-环磷酸腺苷的生成,也作用肾细胞兴奋产生磷酸肌醇酯,并增加胞浆钙浓度。本文介绍肾脏内的腺苷受体及其信息机制的有关知识,提出腺苷为肾功能的反馈调节因子的假说,证实腺苷在肾细胞中的特异细胞机制。
The different mode of action of adenosine in the kidneys is that it has the best evidence of its ability to regulate a number of physiological functions. Adenosine binds to receptors on the cell membrane of the kidney, stimulating the various physiological responses of the kidneys, including hemodynamics, hormones, neurotransmitter release, and changes in renal tubular reabsorption. The extracellular adenosine, which is produced by hydrolysis of 5’-adenosine triphosphate, substrate increase or enzyme reduction, binds to at least two receptors on the cell surface, excites and inhibits the formation of 3 ’, 5’-cyclic adenosine monophosphate and also acts Excitation of kidney cells produces phosphoinositides and increases cytosolic calcium concentration. This article describes the knowledge about the adenosine receptors within the kidneys and their mechanisms of action, and suggests that adenosine is a feedback regulator of renal function, confirming the specific cellular mechanism of adenosine in kidney cells.