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目的:检测FOXP1蛋白在胃癌组织及癌旁正常组织中的表达情况,并探讨其与胃癌患者病理参数及预后的关系。方法:采用免疫组织化学染色方法检测90例胃癌组织和相应癌旁正常组织中FOXP1的表达情况并进行评分,进一步统计分析FOXP1表达与胃癌患者临床病理参数以及预后的关系。结果:FOXP1在胃癌组织中的表达显著低于癌旁正常组织(P<0.01);对临床资料进行统计分析表明,在临床III期和IV期患者的胃癌组织中FOXP1的表达显著低于临床I期和II期的患者(P<0.05);FOXP1在低分化胃癌中的表达显著低于高、中分化胃癌(P<0.01);FOXP1表达阳性者术后总体生存率较表达阴性者高(P=0.145),中位生存期长。结论:FOXP1表达的减少可能参与了胃癌的发生发展,FOXP1在胃癌中可能扮演抑癌基因的角色,FOXP1可作为胃癌治疗的潜在靶点。
OBJECTIVE: To detect the expression of FOXP1 protein in gastric cancer tissues and adjacent normal tissues, and to explore its relationship with pathological parameters and prognosis of gastric cancer patients. Methods: Immunohistochemical staining was used to detect the expression of FOXP1 in 90 cases of gastric cancer and corresponding normal tissues. The relationship between FOXP1 expression and clinical pathological parameters and prognosis was further analyzed. Results: The FOXP1 expression in gastric cancer tissues was significantly lower than that in adjacent normal tissues (P <0.01). Statistical analysis of clinical data showed that FOXP1 expression was significantly lower in clinical stage III and IV gastric cancer tissues than in clinical I (P <0.05). The expression of FOXP1 in poorly differentiated gastric cancer was significantly lower than that in high and moderately differentiated gastric cancer (P <0.01). The overall survival rate of patients with positive FOXP1 expression was significantly higher than that of negative patients = 0.145), the median survival period is long. Conclusion: The decrease of FOXP1 expression may be involved in the development of gastric cancer. FOXP1 may play a role of tumor suppressor gene in gastric cancer. FOXP1 may be a potential therapeutic target for gastric cancer.