Ｗｅｇｅｎｅｒ氏肉芽肿是一种较少见的自身免疫性疾病，多发生于５０～６０岁，男性稍多于女性。病变常常侵犯鼻腔和鼻旁窦，也可侵犯眼、肺、关节、皮肤和神经系统，典型者有局处性肾小球肾炎，有极少数侵犯耳部表现为中耳炎。该文报道２例发生于年轻女性的表现为乳突炎的Ｗ Wegener’s granulomatosis is a rare autoimmune disease that occurs mostly in the 50 to 60 years old, slightly more men than women. Lesions often encroach on the nasal cavity and paranasal sinus, but also violations of the eye, lungs, joints, skin and nervous system, typical of those with focal glomerulonephritis, a small number of violations of the ear showed otitis media. This article reports two cases of young males presenting with mastoiditis