Nowadays, numerous commercial electrocardiographs (ECG) have 500 Hz output sampling rate, i.e., 2 ms corresponding sampling interval. Medical workers who have no background of signal processing may worry about whether such low 500 Hz output sampling rate data could support high-precision estimation of electrocardiogram parameters by being up-sampled. With intention to clarify the problem to the medical workers, this paper takes some simulating experiment to illustrate it. The experiment chose the RR interval and R peak amplitude as representative parameters to be estimated. The obtained results were as follows:for RR interval parameter, its estimation error can be lowered to below 0.3 ms by up-sampling;for R peak amplitude, its estima-tion error can be reduced to below 2.0μV by up-sampling. It is believed that other ECG parameter estimation can also be improved similarly by up-sampling 500 Hz data.