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目前世界很多地区仍有细菌性脑膜炎流行。此病的最常治疗药物是氨苄青霉素、青霉素和氯霉素。作者意在寻找一种既安全又有效的药物代替上述药物,他们发现头孢三嗪体外试验能极有效地对抗脑炎病原菌,易通过血脑屏障且浓度较高,静注或肌注在疗效上完全可与常规疗法相比。本文比较了每天仅用一次头孢三嗪与氨苄青霉素和氯霉素合用,每6h—次治疗细菌性脑炎的效果。试验选择100例(成人30,儿童70)细菌性脑炎患者,随机分为两组,一组用头孢三嗪(CRO)100mg/kg/d,另一组用氨苄青霉素160mg/kg/d和氯霉素100mg/kg/d(AMCL),每6h一次,两组用药均为成人静脉注射,儿
Bacterial meningitis is still endemic in many parts of the world. The most common remedies for the disease are ampicillin, penicillin and chloramphenicol. The authors intended to find a safe and effective alternative to the above drugs, they found that ceftriaxime in vitro tests can be very effective against encephalitis pathogens, easy to pass the blood-brain barrier and high concentrations, intravenous or intramuscular injection in the efficacy Fully comparable with conventional therapies. This article compares once-daily use of cefotaxime with ampicillin and chloramphenicol in combination for 6 h-treatment of bacterial encephalitis. A total of 100 patients (30 adults and 70 children) with bacterial encephalitis were randomly divided into two groups. One group received 100 mg / kg / day of CRO and the other group received ampicillin 160 mg / kg / d and Chloramphenicol 100mg / kg / d (AMCL), once every 6h, two groups of drugs are intravenous injection, children