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目的观察参麦注射液、葡萄糖酸锌及大剂量维生素C(VitC)治疗小儿病毒性心肌炎的疗效及安全性。方法 105例患儿随机分为两组,观察组57例,对照组48例,两组病例均予包括卧床休息、抗病毒、抗心律失常、营养心肌代谢药物等综合治疗。观察组在此基础上,加用参麦注射液、大剂量维生素C静脉滴注,同时口服葡萄糖酸锌,并与对照组比较,疗程14～21 d,动态观察临床症状和体征的消失情况及心电图、心肌酶谱、心脏功能的恢复情况。结果观察组显效率80.70%,总有效率96.49%,在临床症状、体征消失时间、治疗前后心肌酶谱变化情况及心电图恢复时间上与对照组比较差异均有统计学意义。结论在综合治疗的基础上加用参麦注射液、大剂量VitC及葡萄糖酸锌颗粒治疗小儿病毒性心肌炎,能提高治疗效果,缩短病程,且不良反应小,值得推广应用。
Objective To observe the efficacy and safety of Shenmai injection, zinc gluconate and high-dose vitamin C in the treatment of viral myocarditis in children. Methods A total of 105 children were randomly divided into two groups: observation group (57 cases) and control group (48 cases). All cases included bed rest, anti-virus, anti-arrhythmia and nutritional myocardial metabolism. On the basis of this observation, the observation group was treated with Shenmai injection and high-dose vitamin C intravenous infusion simultaneously with oral zinc gluconate, and compared with the control group, the course of treatment was 14-21 days, and the disappearance of clinical symptoms and signs were observed dynamically ECG, myocardial enzymes, recovery of cardiac function. Results The effective rate was 80.70% in the observation group and the total effective rate was 96.49%. There were significant differences between the observation group and the control group in the clinical symptoms, the disappearance of the signs, the change of the myocardial enzymes before and after the treatment and the ECG recovery time. Conclusion The combination of Shenmai injection, high-dose VitC and zinc gluconate granules for the treatment of viral myocarditis in children can improve the curative effect and shorten the course of the disease, and the adverse reaction is small, which is worth popularizing and applying.