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作者报导用争光霉素治疗108例脑瘤的经验。 108例中胶质瘤50例,转移癌12例,脑膜瘤及脑膜肉瘤4例,其它脑瘤7例。给药方法:15毫克每周1—2次静注或5毫克隔日一次肌注。成人300毫克,小儿100—200毫克为一疗程。有些病人同时合用钴~(60)照射。脑室内、蛛网膜下腔、肿瘤囊内给药通常一次5毫克。颈动脉间歇给药一次10—15毫克。每1—2周测定1次血氧分压及PSP在15分钟时的排出值以了解肺和肾功能。发热及皮肤并发病并非停药指征。
The authors report experience with the use of bleomycin for the treatment of 108 brain tumors. Of the 108 cases, 50 were gliomas, 12 were metastatic, 4 were meningioma and meningeal sarcoma, and 7 were other brain tumors. Dosing method: 15 mg weekly 1-2 times intravenously or 5 mg intramuscularly every other day. 300 mg for adults and 100-200 mg for children are a course of treatment. Some patients also used cobalt-60 radiation. The intracerebroventricular, subarachnoid, and intratumoral administration is usually performed at 5 mg once. Carotid artery intermittent administration once 10-15 mg. The blood oxygen partial pressure and the excretion of PSP at 15 minutes were measured every 1 to 2 weeks for lung and renal function. Fever and skin complications are not indications of withdrawal.