慢性粒细胞白血病（ＣＭＬ）是造血干细胞向粒细胞系转化过程异常增生的结果。伴有巨脾的ＣＭＬ对常规化疗疗效不佳，而且易急变，是白血病治疗的难点。我科应用脾动脉灌注化疗药物治疗２例，达到在大剂量应用化疗药物的情况下，副作用少，较快缩小巨脾，迅速降低白细胞作用。 Chronic myeloid leukemia (CML) is the result of abnormal proliferation of hematopoietic stem cells into the granulocyte lineage. CML with giant spleen is not effective for conventional chemotherapy, and it is easy to change rapidly. It is a difficult point for leukemia treatment. Our department applied splenic arterial infusion chemotherapeutic drugs to treat 2 cases, in the case of large doses of chemotherapeutic drugs, fewer side effects, faster reduction of giant spleen, and quickly reduce the role of white blood cells.