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目的探讨联合检测纤维蛋白原和糖化血红蛋白对急性心肌梗死的临床应用价值。方法收集急性心肌梗死患者和正常体检组血浆各60例,采用全自动血凝仪,运用凝固法测定其血浆纤维蛋白原含量,同时运用糖化血红蛋白仪,采用微粒色谱法检测糖化血红蛋白浓度,分析2者浓度的差别,评估其在急性心肌梗死发生风险、预后中的临床价值。结果急性心肌梗死患者的纤维蛋白原及糖化血红蛋白浓度高于对照组,纤维蛋白原含量为(4.48±1.33)g/L;糖化血红蛋白浓度为7.58%±1.52%,差异有统计学意义(P<0.05)。结论纤维蛋白原和糖化血红蛋白与AMI具有相关性,2者在AMI中的差异有统计学意义,这对急性心肌梗死的发生发展、诊断分级和预后具有重大的临床意义。
Objective To investigate the clinical value of combined detection of fibrinogen and glycated hemoglobin in acute myocardial infarction. Methods Sixty patients with acute myocardial infarction (AMI) and normal control group were enrolled in this study. Plasma fibrinogen was measured by coagulation method using automatic coagulation analyzer. Meanwhile, the concentration of HbA1c was measured by the HbA1c, The difference of concentration, to assess their risk of acute myocardial infarction, prognosis of clinical value. Results The concentrations of fibrinogen and glycosylated hemoglobin in patients with acute myocardial infarction were significantly higher than those in the control group (4.48 ± 1.33) g / L and those of glycosylated hemoglobin were 7.58% ± 1.52% (P < 0.05). Conclusions Fibrinogen and glycosylated hemoglobin are correlated with AMI. There is a significant difference between the two in AMI, which is of great clinical significance for the occurrence, development, diagnosis, classification and prognosis of AMI.