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目的 考察博莱霉素治疗颅咽管瘤的疗效、应用方式与副反应。方法 病人随机分成化疗、联合化放疗和放疗三组 ,经立体定向手术分别向囊内注入博莱霉素、博莱霉素与3 2 P以及3 2 P ,比较治疗前后瘤囊容积、症状以及血生化、内分泌指标、乳酸脱氢酶等变化。结果 随访除 2例外 ,所有瘤囊均有不同程度缩小。联合组 6例瘤囊完全消失 ,3例发生严重内分泌紊乱。所有患者血常规、肝肾功能及乳酸脱氢酶均无显著变化。结论 联合化放疗较单独博莱霉素囊内化疗和3 2 P囊内放疗疗效好 ,副反应也更重 ,建议在其他疗法均无效时慎重使用
Objective To investigate the efficacy, application and side effects of bleomycin in the treatment of craniopharyngioma. Methods The patients were randomly divided into three groups: chemotherapy, combination radiotherapy and radiotherapy. Intragastric injection of bleomycin, bleomycin, and 3 2 P and 3 2 P respectively by stereotactic surgery were performed. The volume of the tumor capsule and its symptoms before and after treatment were compared Blood biochemistry, endocrine indicators, such as changes in lactate dehydrogenase. Results except for 2 cases of follow-up, all of the tumor capsule were reduced to varying degrees. In the combined group, the tumor capsule completely disappeared in 6 cases and severe endocrine disorders in 3 cases. All patients with blood, liver and kidney function and lactate dehydrogenase did not change significantly. Conclusion Combined radiotherapy than bleomycin intracapsular chemotherapy alone and 3 2 P intracapsular radiotherapy curative effect is good, side effects are more serious, it is recommended that other treatments are invalid when used with caution