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目的:探讨多巴胺转运体基因(DAT1)多态性与新疆汉族癌症患者性别的关系。方法:采用聚合酶链式反应和VNTR多态性分析技术对新疆汉族癌症患者DAT1多态性进行检测,比较各组间等位基因和基因型频率分布的差异及组内男女性别等位基因和基因型频率分布的差异。结果:在213例无关癌症人群个体中,DAT1 VNTR多态性表现出6～12倍重复的7种等位基因,共检出7种基因型。男女癌症患者的DAT1 VNTR等位基因及基因型频率的差异均无显著性(p>0.05)。结论:多巴胺转运体基因(DAT1)3’端40bp可变串联重复多态性可能与汉族癌症患者的性别无关。
Objective: To investigate the relationship between dopamine transporter gene (DAT1) polymorphism and sex of cancer patients in Xinjiang Han nationality. Methods: Polymerase chain reaction (PCR) and VNTR polymorphism analysis were used to detect the DAT1 polymorphism of cancer patients in Han nationality in Xinjiang. The allele and genotype frequency distribution among different groups were compared. Differences in genotype frequency distribution. RESULTS: Among 213 unrelated cancer individuals, the DAT1 VNTR polymorphism showed 6 to 12-fold repeated 7 alleles and 7 genotypes were detected. There were no significant differences in the frequencies of DAT1 VNTR alleles and genotypes between male and female cancer patients (p> 0.05). CONCLUSION: A 40 bp variable tandem repeat polymorphism at the 3 ’end of the dopamine transporter gene (DAT1) may not be related to sex in Han cancer patients.