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目前尽管发现参与气道高反应性形成的介质较多,但唯有血小板活化因子(PAF)能造成实验动物和部分人的气道反应性持续升高。本文综述了PAF 在哮喘气道高反应性形成中的作用、作用机理以及PAF 拮抗剂的防治作用。
At present, although PAF is found to be involved in the formation of airway hyperresponsiveness, only airway responsiveness of experimental animals and some human beings continues to increase. This article reviews the role of PAF in the formation of airway hyperresponsiveness in asthma, the mechanism of action and the preventive and therapeutic effects of PAF antagonist.